C$364 Cheap Flights from Buffalo Niagara (BUF) to Panama City (PTYA)

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Flight deals from Buffalo Niagara Airport to Panama City

Looking for a cheap last-minute deal or the best return flight from Buffalo Niagara Airport to Panama City? If you want to travel next month, return fares start from C$849. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Buffalo Niagara to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Buffalo Niagara to Panama City flights are currently cheapest in May.

Alternative Buffalo Niagara to Panama City routes

Looking for the cheapest, fastest or easiest route from Buffalo Niagara to Panama City? You could fly into the following airports instead.

Buffalo to Panama City: Flight information

The things to know before you go.
Cheapest flight foundC$364
Cheapest month to flyMay

Finding cheap flights from Buffalo Niagara to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Buffalo Niagara to Panama City is C$815. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Buffalo Niagara to Panama City. But we found flights with one or more stops from C$815.
As of March 2026, there are no flights flying from Buffalo Niagara to Panama City.
The cheapest month to fly from Buffalo Niagara to Panama City is usually May.
If you're flying from Buffalo Niagara Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from C$815.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Buffalo Niagara Airport to Panama City on Monday, May 11, 2026.
No airlines currently offer direct flights between Buffalo Niagara Airport and Panama City. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In March, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, Frontier Airlines offers the cheapest flight tickets to Panama City.

Travelling from Buffalo Niagara International Airport (BUF) to Panama City: what you need to know

  • Panama City is 1 hour behind Buffalo, where Buffalo Niagara International Airport is located. Panama City operates on the UTC-5 timezone.

  • To ensure you get on your flight from BUF to Panama City, allow plenty of time for things like baggage drop and finding your gate. Turning up two hours ahead of international departures and one hour before domestic flights is the general rule.

  • Popular months like August or vacation periods such as Christmas and New Year will mean longer lines at check-in and security. If you're travelling then, play it safe and get to the airport even earlier. Arriving two hours before a domestic flight and up four hours ahead of an international flight is wise.

  • Think about adding a stopover to possibly find a cheaper flight from BUF to Panama City. Simply uncheck 'Direct flights only' when searching for the departures. Take a break (and maybe save some cash) by stopping at one of these popular options:

    • Hartsfield-Jackson Atlanta International Airport (ATL)

    • Orlando International Airport (MCO)

    • Miami International Airport (MIA)

  • If you have a passport from United States and plan to travel to Panama for tourism purposes, you won't need a visa. However, visa and entry requirements may differ based on the duration of your stay and are subject to change. For the most up-to-date information, contact your destination's nearest embassy or consulate before booking a cheap ticket from Buffalo Niagara International Airport to Panama City.

  • BUF is around 18 kilometres from central Buffalo. If you're ride-sharing, driving or catching a cab from the centre, it'll take you 21 minutes or so to get there, depending on traffic. If you're using public transport, expect the travel time to be approximately 1 hour and 15 minutes.

  • After a hassle-free start to your break? Stay near BUF. Whether you're catching an early flight from Buffalo Niagara International Airport to Panama City or just don't like being rushed, these hotels are the answer:

How to find the cheapest flights from Buffalo Niagara International Airport (BUF) to Panama City

  • The lowest price we've seen for a one-way ticket from Buffalo Niagara International Airport to Panama City is C$364. The cheapest price for a return flight is C$815. Keep in mind fares can change due to demand at the time of booking.

  • To get your hands on cheap tickets from BUF to Panama City, book as early as you can. Airlines usually offer their most competitively priced fares when flights are first made available.

  • The 'Whole month' search tool shows you the cheapest tickets from Buffalo Niagara International Airport to Panama City across the entire month. It's an easy way to find a bargain if your travel dates are flexible.

  • Create a Price Alert for cheap tickets from BUF to Panama City. There's no need to check every day to see whether prices have fallen. We'll let you know as soon as the price changes.

  • Tailor your trip with filters. Choose your ideal departure and arrival times, airlines and total journey duration. You can also sort results by 'Cheapest,' 'Fastest' or 'Best' flights from Buffalo Niagara International Airport to Panama City.

Airports in Panama City

Tocumen International Airport (PTY)

Marcos A. Gelabert International Airport (PAC)

Best time to go to Panama City

  • June is the busiest month to board a flight from Buffalo Niagara International Airport to Panama City while February is the quietest. To work out the ideal time to visit Panama City, consider the pace you like to travel at.

  • Before booking a flight from Buffalo Niagara International Airport to Panama City, think about the type of weather you enjoy. March is the warmest month in Panama City, with the temperature ranging from 21ºC to 32ºC.

  • February sees average temperatures of between 22ºC and 31ºC. Search for cheap flights from BUF to Panama City sometime then if you like travelling in cooler conditions.

More about Panama City

  • After locking in your flight from Buffalo Niagara International Airport to Panama City, think about where to rest your head in this city. Make one of these accommodation options your base for exploring Panama City:

  • There are so many things to discover in this city it can be hard to know where to begin. Panama Canal Museum, Casco Viejo and Cinta Costera are major attractions which should feature on any good Panama City itinerary.

Complete your Panama City trip with a car rental

  • We use the same magic that helped you find your cheap flight from Buffalo Niagara International Airport to Panama City to track down deals on car rentals. Search for your ride in seconds and compare your options in one place. Plus you'll find all the info you need to know about car rentals in Panama City, from the most popular rental company to the best time to book.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.