C$145 Cheap Flights from Des Moines (DSM) to St Louis (STL)

Compare Des Moines to St Louis flight deals

Find the cheapest month or even day of the year to fly to St Louis

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Flight deals from Des Moines to St Louis

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to St Louis Airport? If you want to travel next month, return fares start from C$295. Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Des Moines to St Louis

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to St Louis flights are currently cheapest in June.

Des Moines to St Louis: Alternative routes

Compare routes from Des Moines to St Louis below. You may find an airport to fly into that's cheaper, faster, or easier than St Louis.

Des Moines to St Louis: Flight information

The things to know before you go.
Cheapest flight foundC$145
Cheapest month to flyJune

Finding cheap flights from Des Moines to St Louis: Frequently asked questions

The best price we found for a return flight from Des Moines to St Louis is C$295. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to St Louis. But we found flights with one or more stops from C$295.
As of April 2026, there are no flights flying from Des Moines to St Louis.
The cheapest month to fly from Des Moines to St Louis is usually May.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to St Louis Airport on Friday, May 1, 2026.
No airlines currently offer direct flights between Des Moines Airport and St Louis Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to St Louis but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to St Louis is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to St Louis.

Traveling from Des Moines International Airport (DSM) to Lambert-St. Louis International Airport (STL): what you need to know

  • A direct flight from Des Moines International Airport to Lambert-St. Louis International Airport takes on average 1 hour 8 minutes. St Louis's timezone is UTC-5 — identical to Des Moines.

  • For the earliest departure, hop on the 05:10 flight from Des Moines International Airport to Lambert-St. Louis International Airport. If you want to jet off later, the latest flight departs at 22:55. With 10 flights each week from DSM to STL, you can select the one that works best for you.

  • Peak months like July or vacation periods such as spring break and Thanksgiving will mean bigger queues at check-in and security. Play it safe and get to the airport even earlier. Arriving two hours before domestic flights and up four hours ahead of international flights is a smart idea.

  • We make it a breeze to book a flight with a stopover. To see your options for flights from Des Moines International Airport to Lambert-St. Louis International Airport, deselect 'Direct flights only.' Then, pick a flight that has a stop long enough to explore your chosen city. Some popular stopovers between DSM and STL include:

    • O'Hare International Airport

    • Detroit Metropolitan Wayne County Airport

    • Minneapolis-St. Paul International Airport

How to find the cheapest flights from Des Moines International Airport (DSM) to Lambert-St. Louis International Airport (STL)

  • The best price we've found for a one-way ticket from Des Moines International Airport to Lambert-St. Louis International Airport is C$145. The cheapest price for a return flight is C$295. Remember that fares could change due to availability when booking.

  • To snag cheap flight tickets from DSM to STL, reserve your journey 1 month before your planned departure.

  • Organize your trip for September. That's the cheapest month for flight tickets from Des Moines International Airport to Lambert-St. Louis International Airport. If your travel dates are flexible, use the 'Whole month' tool to see the lowest price across each month.

  • Log into your online account or use the app to create a Price Alert. We'll get in touch straight away if there's a better deal on this route. It's easy to do, and it'll save you from checking for cheap flight tickets from DSM to STL every day.

  • Tailor your flights using filters. Pick your preferred departure and arrival times, airlines and total journey duration. You can also sort your results by 'Cheapest,' 'Best' or 'Fastest' flights from Des Moines International Airport to Lambert-St. Louis International Airport.

Handy information about Des Moines International Airport (DSM)

Arriving at Lambert-St. Louis International Airport (STL)

Getting from Lambert-St. Louis International Airport (STL) to central St Louis

  • From Lambert-St. Louis International Airport, St Louis is approximately 26 kilometres away. It takes around 21 minutes to get to the center driving.

  • If you're taking public transport, expect a journey of roughly 36 minutes.

When to fly to Lambert-St. Louis International Airport (STL)

  • It's time to plan your dates for your flight from Des Moines International Airport to Lambert-St. Louis International Airport. July is the busiest month to visit St Louis. If you want a more peaceful vibe, go in April.

  • The warmest month in St Louis is July, with the temperature ranging between 17ºC and 33ºC. Lock in your flights from Des Moines International Airport to Lambert-St. Louis International Airport in this month if this is the kind of weather you like.

  • January has average temperatures of between -8ºC and 7ºC. Search for cheap flight tickets from DSM to STL sometime around then if you'd rather travel in cooler conditions.

More about St Louis

Complete your St Louis trip with hotels and a car rental

  • Comparing flights is not our only party trick. After booking your cheap ticket to Lambert-St. Louis International Airport, check out our great car rental offers that'll give you the flexibility to travel around at your own pace. Then, have a look at our exclusive rates for hotels to find your ideal St Louis stay.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.