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C$173 Cheap Flights from Knoxville (TYS) to San Diego (SANA)

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Flight deals from Knoxville to San Diego

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to San Diego? If you want to travel next month, return fares start from C$370. Find the lowest prices on one-way and return tickets right here.
San Diego.C$173 per passenger.Departing Thu., Sep. 10.One-way flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departs from Knoxville on Thu., Sep. 10, arriving in San Diego International.Price includes taxes and charges.From C$173, select.
San Diego.C$193 per passenger.Departing Wed., Jun. 17.One-way flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Knoxville on Wed., Jun. 17, arriving in San Diego International.Price includes taxes and charges.From C$193, select.
San Diego.C$217 per passenger.Departing Sun., Jul. 12.One-way flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departs from Knoxville on Sun., Jul. 12, arriving in San Diego International.Price includes taxes and charges.From C$217, select.
San Diego.C$232 per passenger.Departing Sat., Aug. 15.One-way flight with United.Outbound indirect flight with United, departs from Knoxville on Sat., Aug. 15, arriving in San Diego International.Price includes taxes and charges.From C$232, select.
San Diego.C$269 per passenger.Departing Sun., Oct. 18.One-way flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departs from Knoxville on Sun., Oct. 18, arriving in San Diego International.Price includes taxes and charges.From C$269, select.
San Diego.C$294 per passenger.Departing Fri., May 22.One-way flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Knoxville on Fri., May 22, arriving in San Diego International.Price includes taxes and charges.From C$294, select.

Find the cheapest month to fly from Knoxville to San Diego

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to San Diego flights are currently cheapest in September.
May
from C$294
Jun.
from C$193
Jul.
from C$217
Aug.
from C$232
Sep.
from C$173
Oct.
from C$269
Nov.
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Dec.
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Jan.
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Feb.
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Mar.
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Apr.
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Alternative Knoxville to San Diego routes

Looking for the cheapest, fastest or easiest route from Knoxville to San Diego? You could fly into the following airports instead.

San Diego International

4km from central San Diego
ClosestCheapest
from C$173
Search flights

McClellan-Palomar

48km from central San Diego
from C$451
Search flights

Knoxville to San Diego: Flight information

The things to know before you go.
Cheapest flight foundC$173
Cheapest month to flySeptember

Finding cheap flights from Knoxville to San Diego: Frequently asked questions

There are 2 airports in San Diego: San Diego International and McClellan-Palomar.
The best price we found for a return flight from Knoxville to San Diego is C$351. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to San Diego. But we found flights with one or more stops from C$350.
As of May 2026, there are no flights flying from Knoxville to San Diego.
The cheapest month to fly from Knoxville to San Diego is usually September.
If you're flying from Knoxville Airport, the cheapest airport near San Diego is San Diego International – which is 4.1 km away from the centre of San Diego. We've found flights into this airport from C$351.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to San Diego on Sunday, September 6, 2026.
No airlines currently offer direct flights between Knoxville Airport and San Diego. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to San Diego but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to San Diego is around 40 days in advance, so don’t leave your flight to the last minute.
In May, the average temperature is usually around 17°C. August is typically the warmest month in San Diego, when it usually averages around 28°C. You can expect the least rain in June. The coldest month is December, with temperatures averaging 10°C. The rainiest month is February.
Currently, Allegiant Air offers the cheapest flight tickets to San Diego.

Travelling from McGhee Tyson Airport (TYS) to San Diego: what you need to know

  • The timezone in San Diego is UTC-7. The city is 3 hours behind Knoxville, where McGhee Tyson Airport is located.

  • Give yourself plenty of time to get on your flight from TYS to San Diego. It's generally best to arrive two hours before international departures and an hour ahead for domestic flights.

  • Peak months like July or vacation times such as spring break and Thanksgiving will mean bigger queues at check-in and security. Travelling then? Play it safe and head to the airport even earlier. Arriving two hours before domestic flights and up four hours ahead of international flights is a wise move.

  • You don't need a visa or passport to fly within United States. You will need a valid identity document however, such as a driver's licence or an ID card. Add them to your packing checklist once you've booked flight tickets from McGhee Tyson Airport to San Diego.

  • Central Knoxville to TYS is approximately 23 kilometres. Depending on traffic, it'll take you about 19 minutes to reach there if you're driving, catching a cab or ride-sharing.

  • Looking for a handy hotel near TYS? If you're catching an early flight from McGhee Tyson Airport to San Diego, these accommodation options will have you moments from your check-in counter:

How to find the cheapest flights from McGhee Tyson Airport (TYS) to San Diego

  • The lowest price we've found for a one-way ticket from McGhee Tyson Airport to San Diego is C$173. The cheapest price for a return flight is C$350. Remember fares can change due to availability at the time of booking.

  • Don't wait until the last moment. You're more likely to get cheap tickets from TYS to San Diego if you book ahead. Airlines often offer some excellent early bird rates.

  • Finding cheap tickets from McGhee Tyson Airport to San Diego is easy if you can be flexible with your trip dates. Try using the 'Whole month' search function to see the lowest fares across each month and land a great deal.

  • Snapping up a cheap ticket from TYS to San Diego is easy with Price Alerts. All you need to do is set up one of these automatic alerts and we'll get in touch when there's a better deal.

  • Make the most of the filters to find your ideal trip. To see the 'Cheapest,' 'Fastest' or 'Best' flights from McGhee Tyson Airport to San Diego, use the 'Sort by' function. You can also filter by airline, departure and arrival times, and journey duration.

Airports in San Diego

San Diego International Airport (SAN)

  • San Diego International Airport (SAN) is around 5 kilometres from central San Diego. With a cab or in your own car rental, the drive is around 9 minutes.

  • If you're travelling on public transport, expect a journey of roughly 20 minutes.

  • Reserve a hotel close to SAN if you're catching a late flight from McGhee Tyson Airport to San Diego. Settle into one of these accommodation options and avoid the hassle of a long transfer:

McClellan-Palomar Airport (CLD)

  • The centre of San Diego is approximately 56 kilometres from McClellan-Palomar Airport (CLD). As soon as your flight from McGhee Tyson Airport to San Diego has hit the runway and you've made your way through the terminal, expect a drive of about 39 minutes.

  • Travelling by public transport will take about 2 hours and 14 minutes.

  • After your flight from TYS to San Diego, unwind at a hotel close to CLD. These are some comfortable accommodation options that'll help you sink into relaxation mode:

Best time to go to San Diego

  • It's time to choose your travel dates for your flight from McGhee Tyson Airport to San Diego. July is the busiest month to visit San Diego. If you want a more relaxed vibe, go in May.

  • The warmest month in San Diego is August, with temperatures ranging between 17ºC and 28ºC. Book your flights from McGhee Tyson Airport to San Diego in this month if this is the type of weather you enjoy.

  • If you'd rather travel in cooler conditions, look for a cheap flight from TYS to San Diego in February when temperatures average between 7ºC and 23ºC.

More about San Diego

Complete your San Diego trip with a car rental

  • Choose one of our car rentals in San Diego and explore the city on your own terms. Easily compare options in one place to find the perfect ride after booking your hotel and cheap flights from McGhee Tyson Airport to San Diego.

Plan the rest of your trip from Knoxville to San Diego

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.