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Flights from San Diego to South Carolina

Flight deals from San Diego to South Carolina

Looking for cheap flights from San Diego to South Carolina, or a last-minute trip? Find the lowest prices on one-way and round-trip flights right here.
Myrtle Beach.C$398 per passenger.Departing Thu, Oct 2, returning Mon, Oct 6.Round-trip flight with Frontier Airlines and Spirit Airlines.Outbound indirect flight with Frontier Airlines, departing from San Diego International on Thu, Oct 2, arriving in Myrtle Beach International.Inbound indirect flight with Spirit Airlines, departing from Myrtle Beach International on Mon, Oct 6, arriving in San Diego International.Price includes taxes and charges.From C$398, select.
Charleston.C$399 per passenger.Departing Wed, Oct 29, returning Tue, Nov 4.Round-trip flight with United.Outbound indirect flight with United, departing from San Diego International on Wed, Oct 29, arriving in Charleston.Inbound indirect flight with United, departing from Charleston on Tue, Nov 4, arriving in San Diego International.Price includes taxes and charges.From C$399, select.
Columbia.C$416 per passenger.Departing Tue, Sep 23, returning Thu, Sep 25.Round-trip flight with Spirit Airlines.Outbound indirect flight with Spirit Airlines, departing from San Diego International on Tue, Sep 23, arriving in Columbia Metropolitan.Inbound indirect flight with Spirit Airlines, departing from Columbia Metropolitan on Thu, Sep 25, arriving in San Diego International.Price includes taxes and charges.From C$416, select.
Greenville.C$488 per passenger.Departing Fri, Nov 7, returning Mon, Nov 10.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from San Diego International on Fri, Nov 7, arriving in Greenville-Spartanburg.Inbound indirect flight with Delta, departing from Greenville-Spartanburg on Mon, Nov 10, arriving in San Diego International.Price includes taxes and charges.From C$488, select.

Flying from San Diego to South Carolina

Arm yourself with these facts on the fly.
Cheapest flight foundC$137, Columbia
Cheapest month to flyOctober
Cheapest airport to fly fromSan Diego International

Frequently asked questions

We looked at all of the upcoming round-trip flights from San Diego to South Carolina we could find over the next 12 months. It looks like C$395 is the best price. This is good, compared to the average South Carolina ticket price of C$425.
The cheapest month to fly from San Diego to Myrtle Beach International Airport is usually October. The cheapest month to fly from San Diego to Columbia Metropolitan Airport is usually September. The cheapest month to fly from San Diego to Greenville-Spartanburg Airport is usually November. And the cheapest month to fly from San Diego to Charleston Airport is usually October.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from San Diego to South Carolina on Thursday, October 2, 2025.
Currently, there aren't any direct flights from San Diego to South Carolina, but you can still fly with a stopover.
If you're flying from San Diego, the cheapest city in South Carolina to fly into is Myrtle Beach. The cheapest airport serving Myrtle Beach at the moment is Myrtle Beach International.